My research 

Development of biological dyes and imaging technology

Shum J, Lee LC, Chiang MW, Lam YW, Lo KK. A Concerted Enzymatic and Bioorthogonal Approach for Extracellular and Intracellular Activation of Environment‐Sensitive Ruthenium (II)‐Based Imaging Probes and Photosensitizers. Angewandte Chemie. 2023 May 16:e202303931.

 

Huang L, Leung PKK, Lee LCC, Xu GX, Lam YW, Lo KKW. Photofunctional cyclometallated iridium (iii) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications. Chemical Communications 58 (73), 10162-10165

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Hu P, Berning K, Lam YW, Ng IH, Yeung CC, Lam MH. Development of a Visible Light Triggerable Traceless Staudinger Ligation Reagent. The Journal of organic chemistry. 2018 Oct 15;83(21):12998-3010.

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Shen W, Shen Y, Lam YW, Chan D. Live Imaging of Planaria. Methods Mol Biol. 2018;1774:507-518. 

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Zhang H, Xiao P, Wong YT, Shen W, Chhabra M, Peltier R, Jiang Y, He Y, He J, Tan Y, Xie Y, Ho D, Lam YW, Sun J, Sun H. Construction of an alkaline phosphatase-specific two-photon probe and its imaging application in living cells and tissues. Biomaterials. 2017 Sep 1;140:220-9. 

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Liu CC, Li L, Lam YW, Siu CW, Cheng SH. (2016) Improvement of surface ECG recording in adult zebrafish reveals that the value of this model exceeds our expectation. Sci Rep. 2016 Apr 29;6:25073. 

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Babaei F, Hong TL, Yeung K, Cheng SH, Lam YW. (2016) Contrast-Enhanced X-Ray Micro-Computed Tomography as a Versatile Method for Anatomical Studies of Adult Zebrafish. Zebrafish. 2016 Aug;13(4):310-6. 

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Tan Y, Liu R, Zhang H, Peltier R, Lam YW, Zhu Q, Hu Y, Sun H. (2015). Design and Synthesis of Near- infrared Fluorescent Probes for Imaging of Biological Nitroxyl. Sci Rep. 2015 Nov 20;5:16979. doi: 10.1038/srep16979.

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Zhang H, Xie Y, Wang P, Chen G, Liu R, Lam YW, Hu Y, Zhu Q, Sun H. (2015) An iminocoumarin benzothiazole-based fluorescent probe for imaging hydrogen sulfide in living cells. Talanta. 2015 Apr;135:149-54. 

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Dong H, Cheung SH, Liang Y, Wang B, Ramalingam R, Wang P, Sun H, Cheng SH, Lam YW. "Stain-omics": Identification of mitotracker labeled proteins in mammalian cells. Electrophoresis. 2013 Jul;34(13):1957-64. 

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Li SPY, Lau C, Louie MW, Lam YW, Cheng SH, Lo K. Mitochondria-Targeting Cyclometalated Iridium(III) Poly(ethylene glycol) (PEG) Complexes with Tunable Photodynamic Activity. Biomaterials. 2013 Oct;34(30):7519-32. 

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Wang BJ, Liang YM, Dong HJ, Tan TF, Zhan B, Cheng JP, Lo KKW, Lam YW*, Cheng SH*. A luminescent cyclometalated Iridium(III) complex accumulates in mitochondria and induces mitochondrial shortening by conjugation to specific protein targets. Chembiochem. 2012 Dec 21;13(18):2729-37 *Co-corresponding authors.

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Dong HJ, Shen W, Cheung MTW, Liang YM, Cheung HY, Allmaier G, Au OKC, Lam YW. Rapid detection of apoptosis in mammalian cells by using intact cell MALDI mass spectrometry. Analyst. 2011, 136: 5181-5189.

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Louie MW, Liu HW, Lam MHC, Lam YW, Lo KKW. Rhenium(I) Polypyridine Complexes Appended with an α-D-Glucose Moiety as Luminescent Biomolecular and Cellular Probes. Chemistry. 2011 Jul 18;17(30):8304-8. 

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Zhang KY, Li SP, Zhu N, Or IW, Cheung MS, Lam YW, Lo KK. Structure, Photophysical and Electrochemical Properties, Biomolecular Interactions, and Intracellular Uptake of Luminescent Cyclometalated Iridium(III) Dipyridoquinoxaline Complexes. Inorg Chem. 2010 Mar 1;49(5):2530-40. 

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Koo CK, So LK, Wong KL, Yu HM, Lam YW, MHW Lam, Cheah KW, Cheng CCW, Kowk WM. A Triphenylphosphonium-Functionalized Cyclometalated Platinum(II) Complex as a Nucleolus-Specific Two-Photon Molecular Dye. Chemistry. 2010 Apr 6;16(13):3942-50. Cover story of the issue

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So LK, Cheung SK, Ma HL, Chen XP, Cheng SH, Lam YW. In Situ Labeling of Transcription Sites in Marine Medaka. J Histochem Cytochem. 2010; 58: 173-181 

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Koo CK, Wong KL, Man CW, Lam YW, So LK, Tam HL, Tsao SW, Cheah KW, Lau KC, Yang YY, Chen JC, Lam MH. A bioaccumulative cyclometalated platinum(II) complex with two-photon-induced emission for live cell imaging. Inorg Chem. 2009 Feb 2;48(3):872-8

 

Lau JS, Lee PK, Tsang KH, Ng CH, Lam YW, Cheng SH, Lo KK. Luminescent cyclometalated iridium(III) polypyridine indole complexes--synthesis, photophysics, electrochemistry, protein-binding properties, cytotoxicity, and cellular uptake. Inorg Chem. 2009 Jan 19;48(2):708-18 

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Trinkle-Mulcahy L., Chusainow J, Lam YW, Swift S, Lamond AI. Visualization of intracellular PP1 targeting through transiently and stably expressed fluorescent protein fusions. Methods in Molecular Biology. Vol. 365:133-54; Protein Phosphatase Protocols, Ed. G. Moorhead, Humana Press, 2006.

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Swift SR, Thomson C, Appleton P, Lam YW, Trinkle-Mulcahy L. Basic principles deconvolution microscopy. Proc. Royal Mic. Soc., 40, 2005.

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Trinkle-Mulcahy L, Andrews PD, Wickramasinghe S, Sleeman J, Prescott A, Lam YW, Lyon C, Swedlow JR, Lamond AI. Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycle. Mol Biol Cell. 2003 Jan;14(1):107-17. Cover story of that issue