My research 

Functional organisation of the cell nucleus

Lam YW, Trinkle-Mulcahy L (2015). New insights into nucleolar structure and function. F1000Prime Rep. 2015 Apr 2;7:48. doi: 10.12703/P7-48. 

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Li ZF, Lam YW. A new rapid method for isolating nucleoli. Methods Mol Biol. 2015;1228:35-42. 

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Li ZF, Lau PN, Shen W, Wang DK, Chenung WT, Xue JC, Poon LM, Lam YW. Dynamic localisation of mature microRNAs in human nucleoli is influenced by exogenous genetic materials. PLoS One, 2013 8(8): e70869. 

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Liang YM, Wang X, Rajkumar R, So KY, Lam YW*, Li ZF*. Novel nucleolar isolation method reveals rapid response of human nucleolar proteomes to serum stimulation. J Proteomics. 2012 Dec 21;77:521-30. *Co-corresponding authors.

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Hutten S, Prescott A, James J, Riesenberg S, Boulon S, Lam YW, Lamond AI. An intranucleolar body associated with rDNA. Chromosoma. 2011 Oct;120(5):481-99 Evaluated by BioMed Central Faculty of 1000 as “Recommended” (see http://f1000.com/11705956).

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Kar B, Liu BH, Zhou ZJ, Lam YW. Quantitative nucleolar proteomics reveals nuclear re-organization during stress-induced senescence in mouse fibroblast. BMC Cell Biology. 12:33. 

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Westman BJ, Verheggen C, Hutten S, Lam YW, Bertrand E, Lamond AI. A proteomic screen for nucleolar SUMO targets shows SUMOylation modulates the function of Nop5/Nop58. Mol Cell. 2010 Aug 27;39(4):618-31. 

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Lam YW, Evans VC, Heesom KJ, Lamond AI, Matthews DA. Proteomic analysis of the nucleolus in adenovirus-infected cells. Mol Cell Proteomics. 2010 Jan;9(1):117-30 

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Gu YJ, Cheng J, Lin CC, Lam YW, Cheng SH, Wong WT. Nuclear penetration of surface functionalized gold nanoparticles. Toxicol Appl Pharmacol. 2009 Jun 1;237(2):196-204. 

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Cheng JP, Fernando KAS, Veca LM, Sun YP, Lamond AI, Lam YW*, and Cheng SH*. Reversible Accumulation of PEGylated Single-Walled Carbon Nanotubes in the Mammalian Nucleus. ACS Nano. 2008, 2 (10), pp 2085–2094) *Co-corresponding authors. Publication of note, NCI Alliance for Nanotechnology in Cancer

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Fan J, Li H, Jiang J, So LK, Lam YW, Chu PK. 3C-SiC nanocrystals as fluorescent biological labels. Small. 2008 4(8): 1058-62. 

 

Lam YW, Lamond, A.I., Mann, M. and Andersen, J.S. Analysis of nucleolar protein dynamics reveals the nuclear degradation of ribosomal proteins. Current Biology. 2007 17, 749-769. Featured in the “New and View” article in Curr Biol, May 2007 issue. Featured in “Research Highlight” , Nature Reviews Molecular Cell Biology 8, 427 (June 2007)

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Leung AK, Trinkle-Mulcahy L, Lam YW, Andersen JS, Mann M, Lamond AI. NOPdb: Nucleolar Proteome Database. Nucleic Acids Res. 2006 Jan 1;34:D218-20. 

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Lam YW, Lamond AI. Isolation of nucleoli. In Cell Biology: A Laboratory Handbook. 3rd edition. Edited by Celis J,  Carter N, Simons K, Small J, Hunter T, Shotton D. 2006. Elsevier/Academic Press. 

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Lam YW, Lamond AI. Isolation of Cajal bodies. In Cell Biology: A Laboratory Handbook. 3rd edition. Edited by Celis J,  Carter N, Simons K, Small J, Hunter T, Shotton D. 2006. Elsevier/Academic Press. 

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Andersen JS*, Lam YW*, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M. Nucleolar proteome dynamics. Nature 2005 Jan 6;433(7021):77-83. (713 citations. IF 31.4, ranked top 5% in multidisciplinary) *Co-first authors. Nature Top Ten” most downloaded paper in January 2005. Featured in Nature “Editor’s summary” (6th January, 2005). Evaluated by BioMed Central Faculty of 1000 as “Must Read”. Featured as “Hot paper” in The Scientist magazine, March 2007 issue

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Pendle AF, Clark GP, Boon R, Lewandowska D, Lam YW, Andersen J, Mann M, Lamond AI, Brown JW, Shaw PJ. Proteomic analysis of the Arabidopsis nucleolus suggests novel nucleolar functions. Mol Biol Cell. 2005 Jan;16(1):260-9. Featured in the newsletter of American Society of Cell Biology, January 2005

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Lam YW, Trinkle-Mulcahy L, Lamond AI. The nucleolus. J Cell Sci. 2005 Apr 1;118 (Pt 7):1335-7. 

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Leung AK, Gerlich D, Miller G, Lyon C, Lam YW, Lleres D, Daigle N, Zomerdijk J, Ellenberg J, Lamond AI. Quantitative kinetic analysis of nucleolar breakdown and reassembly during mitosis in live human cells. J Cell Biol. 2004 Sep 13;166(6):787-800. Evaluated by BioMed Central Faculty of 1000 as “Recommended” 

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Lam YW, Fox AH, Leung AK, Andersen, JS, Mann M, Lamond AI. Proteomics of the nucleolus. In The Nucleolus, Edited by Olson M. 2003. Landes Bioscience /Eurekah.Com; New York, N.Y.  

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Lam YW, Lyon CE, Lamond AI. Large-scale isolation of Cajal bodies from HeLa cells. Mol Biol Cell. 2002 Jul;13(7):2461-73. Evaluated by BioMed Central Faculty of 1000 as “Recommended” 

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Fox AH, Lam YW, Leung AK, Lyon CE, Andersen J, Mann M, Lamond AI. Paraspeckles: a novel nuclear domain. Curr Biol. 2002 Jan 8;12(1):13-25. Evaluated by BioMed Central Faculty of 1000 as “Recommended” 

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Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI. Directed proteomic analysis of the human nucleolus. Curr Biol. 2002 Jan 8;12(1):1-11. Cover story of that issue. Evaluated by BioMed Central Faculty of 1000 as “Must Read”. News and Views” articles in Science, Nat Cell Biol., Mol Cell., Curr Biol., Trends Biochem Sci. and BioITWorld.com

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Lam YW, Ammerlaan W, O WS, Kroese F, Opstelten D. Cell type- and differentiation stage-dependent expression of PML domains in rat, detected by monoclonal antibody HIS55. Exp Cell Res. 1995 Dec;221(2):344-56.